Non-Peptide Gonadotropin-Releasing Hormone Receptor AntagonistsBETZ, Stephen F; ZHU, Yun-Fei; CHEN CHEN et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 12, pp 3331-3348, issn 0022-2623, 18 p.Article

Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonistsZHIQIANG GUO; ZHU, Yun-Fei; QIU XIE et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 5, pp 1259-1271, issn 0022-2623, 13 p.Article

5-Aryluracils as potent GnRH antagonists : Characterization of atropisomersLIREN ZHAO; ZHIQIANG GUO; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3344-3349, issn 0960-894X, 6 p.Article

Discovery of Sodium R-(+)-4-{2 [5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1 -yl] -1 -phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorCHEN CHEN; DONGPEI WU; YONGSHENG CHEN et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 23, pp 7478-7485, issn 0022-2623, 8 p.Article

Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonistsROWBOTTOM, Martin W; TUCCI, Fabio C; ZHU, Yun-Fei et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 9, pp 2269-2274, issn 0960-894X, 6 p.Article

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activityCHEN CHEN; YONGSHENG CHEN; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3301-3305, issn 0960-894X, 5 p.Article

Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5ROWBOTTOM, Martin W; TUCCI, Fabio C; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 19, pp 4967-4973, issn 0960-894X, 7 p.Article

Identification of 1-arylmethyl-3-(2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonistsZHU, Yun-Fei; GROSS, Timothy D; BONNEVILLE, Anne L et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 11, pp 2023-2026, issn 0022-2623, 4 p.Article

Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteinsZHU, Yun-Fei; WANG, Xiao-Chuan; LING, Nicholas et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 11, pp 1931-1934, issn 0960-894X, 4 p.Article

A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonistsTUCCI, Fabio C; ZHU, Yun-Fei; ZHIQIANG GUO et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 23, pp 3491-3495, issn 0960-894X, 5 p.Article

Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonistsMI CHEN; ZHIQIANG GUO; BRADBURY, Margaret J et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 14, pp 3845-3850, issn 0960-894X, 6 p.Article

Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902STRUTHERS, R. Scott; QUI XIE; MAKI, Richard A et al.Endocrinology (Philadelphia). 2007, Vol 148, Num 2, pp 857-867, issn 0013-7227, 11 p.Article

Selection, synthesis, and structure-activity relationship of tetrahydropyrido [4,3 -d]pyrimidine -2,4 -diones as human GnRH receptor antagonistsLANIER, Marion C; FEHER, Miklos; ASHWEEK, Neil J et al.Bioorganic & medicinal chemistry. 2007, Vol 15, Num 16, pp 5590-5603, issn 0968-0896, 14 p.Article

Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomersZHIQIANG GUO; YONGSHENG CHEN; WADE, Warren et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 10, pp 2519-2522, issn 0960-894X, 4 p.Article

Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylamino-pyrazolo[1,5-a] pyrimidine (NBI 30775/r121919) and structure-activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonistsCHEN CHEN; WILCOXEN, Keith M; BOZIGIAN, Haig et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 19, pp 4787-4798, issn 0022-2623, 12 p.Article

Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH receptorTUCCI, Fabio C; ZHU, Yun-Fei; ZHIQIANG GUO et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 19, pp 3317-3322, issn 0960-894X, 6 p.Article

Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonistsWILCOXEN, Keith M; ZHU, Yun-Fei; CONNORS, Patrick J et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 16, pp 2179-2183, issn 0960-894XArticle

Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonistsZHIQIANG GUO; YONGSHENG CHEN; DONGPEI WU et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 20, pp 3617-3622, issn 0960-894X, 6 p.Article

Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteinsCHEN CHEN; ZHU, Yun-Fei; LIU, Xin-Jun et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 23, pp 4001-4010, issn 0022-2623Article

A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonistsZHIQIANG GUO; DONGPEI WU; ZHU, Yun-Fei et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 3, pp 693-698, issn 0960-894X, 6 p.Article

Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonistsZHIQIANG GUO; DONGPEI WU; SAID, Yang et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 16, pp 3685-3690, issn 0960-894X, 6 p.Article

1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonistsHUANG, Charles Q; BAKER, Tracy; WANG, Xiao-Chuan et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 16, pp 3701-3706, issn 0960-894X, 6 p.Article

Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1, 2-a]pyrimid-5-ones as potent GnRH receptor antagonistsZHU, Yun-Fei; ZHIQIANG GUO; SAUNDERS, John et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 9, pp 1769-1772, issn 0022-2623, 4 p.Article

A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonistsZHU, Yun-Fei; WILCOXEN, Keith; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 3, pp 403-406, issn 0960-894XArticle

Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonistsGROSS, Timothy D; ZHU, Yun-Fei; SAUNDERS, John et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 16, pp 2185-2187, issn 0960-894XArticle